MOTS-C

MOTS-c is a 16-amino-acid mitochondrial-derived research peptide, encoded within the mitochondrial 12S rRNA region, studied for its role in metabolic regulation and cellular stress resistance. Investigated for its indirect activation of the AMPK energy-sensing pathway—and its ability to translocate to the nucleus to influence antioxidant and metabolic gene expression—MOTS-c offers researchers a unique lens into how the mitochondria communicate with the broader cell to govern metabolism and adaptation.